SAMHD1 is a barrier to antimetabolite-based cancer therapies
نویسندگان
چکیده
The outcome of acute myelogenous leukemia (AML) therapy depends on the propensity of leukemic blasts to accumulate ara-CTP, the active triphosphate of cytarabine (ara-C). We identified sterile α motif and HD domain-containing protein 1 (SAMHD1) as an ara-CTPase that protects cancer cells from cytarabine-induced toxicity. Therefore, we propose targeting SAMHD1 as a strategy to potentiate cytarabine and possibly other antimetabolite-based therapies.
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عنوان ژورنال:
دوره 4 شماره
صفحات -
تاریخ انتشار 2017